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US 6,887,469 B2Granted
Anti-idiotypic antibodies of vascular endothelial growth factor and use thereof as drugs
AssigneeCentre National De La Recherche Scientifique
InventorsJean Plouet, Frederic Jonca, Nathalie Ortega, Marie-Magdeleine Ruchoux
Life of this patent
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Abstract
An anti-idiotypic vascular endothelial growth factor antibody, an Fab fragment, and pharmaceutical compositions thereof, being ligands of the human KDR receptor or of the murine flk-1 receptor and not a ligand of flt are provided.
Claims10
Anti-idiotypic vascular endothelial growth factor antibody, said antibody being a ligand of the human KDR receptor or of the murine flk-1 receptor and not a ligand of flt.
Anti-idiotypic vascular endothelial growth factory antibody, having the following properties:
- a) it targets angiogenic endothelial cells,
- b) it is circulating,
- c) it has a half-life of about 23 days,
- d) it induces phosphorylation on a tyrosine of a protein of 200 kDa,
- e) it induces proliferation of vascular endothelial cells,
- f) it does not induce migration of endothelial cells,
- g) it stimulates angiogenesis,
- h) it does not cause arterial hypotension, and
- i) it does not affect the permeability of vessels.
6 more elements
Dependencies are inferred from the claim text.