Advanced antigen presentation platform
AssigneeBioCache Pharmaceuticals, Inc.
InventorsTimothy P. Coleman, Darrell L. Peterson
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Abstract
The present invention provides particles for the presentation of haptens for the purpose of eliciting an immune response. The amino acid sequences of the monomers which make up the particles are derived from duck hepatitis B virus core protein. The particles may also deliver nucleic acids. The nucleic acids may be delivered for the purpose of enhancing an immune response, or for other purposes such as gene therapy.
Claims9
A composition comprising a plurality of recombinant nucleocapsid protein monomers, the primary sequence of which are derived from duck hepatitis B virus (HBV), wherein at least a first portion of said monomers has been genetically altered such that a first non-HBV hapten has been inserted into its amino acid sequence, and wherein said monomers may be assembled to form a particle antigenic with respect to said hapten.
A composition comprising
- recombinant duck HBcAg;
- and
- a non-HBV hapten, said hapten being genetically engineered linked to said duck HbcAg;
- and
- wherein said recombinant duck HbcAg is capable of disassembly
- and reassembly into an immunogenic particle.
Dependencies are inferred from the claim text.