Implantable or insertable medical device resistant to microbial growth and biofilm formation

An implantable or insertable medical device comprising:

• (a) bioactive agents comprising (i) an antimicrobial agent selected from the group consisting of triclosan, chlorhexidine and mixtures thereof and (ii) a microbial attachment/biofilm synthesis inhibitor selected from the group consisting of salicylic acid and salts and derivatives thereof;
• and
• (b) at least one biocompatible matrix polymer region comprising (i) one or more polymeric materials selected from the group consisting of ethylene vinyl acetate copolymers, copolymers of ethylene with acrylic acid or methacrylic acid, metallocene catalyzed polyethylenes and polyethylene copolymers, ionomers, vinyl aromatic copolymers, elastomeric polyurethanes and polyurethane copolymers, silicones and mixtures thereof;
• and (ii) one or more of said bioactive agents dispersed throughout,
• wherein said bioactive agents are present in said device in an amount effective to inhibit microbial growth on the device for a period of at least 30 days after implantation or insertion of said device into a subject,
• wherein said medical device comprises at least one biocompatible matrix polymer region that is not a coating, and
• wherein the medical device is selected from the group consisting of a stent cover, a biliary stent, a ureteral stent, a pancreatic stent, a urinary catheter, a venous access device, a peritoneal access device, a device connecting or providing drainage between two sterile body environments, and a device connecting or providing drainage between a non-sterile and a sterile body environment.