Microparticles with adsorbent surfaces, methods of making same, and uses thereof
AssigneeChiron Corporation
InventorsDerek O'Hagan, Manmohan Singh, Gary Ott
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Abstract
The present invention is directed to microparticles, to microparticle compositions containing the same, to methods of forming the same, and to uses for the same, including use for a vaccine, for raising an immune response, for treatment of a disease and for diagnosis of a disease. The microparticles comprise a biodegradable polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, or a polycyanoacrylate, and a detergent selected from a cationic detergent and an anionic detergent. The microparticles further comprise an antigen adsorbed on the surface of the microparticle.
Claims53
A microparticle comprising:
- a polymer selected from the group consisting of a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and a polycyanoacrylate;
- a cationic detergent;
- and an antigen comprising a polynucleotide adsorbed on the surface of said microparticle,
- wherein said microparticle is formed by a process that comprises:
- forming a microparticle comprising said polymer and said detergent, said microparticle being formed in the presence of said detergent;
- and exposing said microparticle to said antigen.
A microparticle comprising:
- a biodegradable polymer;
- a cationic detergent;
- and an antigen comprising a polynucleotide adsorbed on the surface of said microparticle,
- wherein said microparticle is formed by a process that comprises:
- forming a microparticle comprising said polymer and said detergent, said microparticle being formed in the presence of said detergent;
- and exposing said microparticle to said antigen.
Dependencies are inferred from the claim text.