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AssigneesSymbiotec GmbH, Philadelphia Health and Education Corporation
InventorsReiner Class, Michael Zeppezauer
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The invention includes antibiotic pharmaceutical compositions comprising eukaryotic histone H1 protein and methods of using eukaryotic histone H1 protein to kill or to inhibit the growth of microorganisms, including, but not limited to, human pathogenic bacteria. The invention further includes a eukaryotic histone H1-containing animal feed and methods of improving growth of an animal by supplying the feed to the animal. The invention still further includes a kit comprising a eukaryotic histone H1-containing antibiotic pharmaceutical composition and an instructional material which describes the use of the composition. In addition, the invention includes a vaccine comprising a eukaryotic histone H1 protein and a method of vaccinating an animal using the vaccine.
An antimicrobial composition comprising a substantially purified eukaryotic histone H1 protein which exhibits antibiotic activity and interacts with a cell membrane of a microorganism and changes or disrupts the cell membrane, whereby at least one of death of the microorganism and inhibition of growth of the microorganisms is induced, wherein the histone H1 protein is covalently linked with polyethylene glycol.
An antimicrobial composition comprising a eukaryotic histone H1 protein which exhibits antibiotic activity and interacts with a cell membrane of a microorganism and changes or disrupts the cell membrane, whereby at least one of death of the microorganism and inhibition of growth of the microorganisms is induced, and further comprising a second antimicrobial composition comprising an antibiotic selected from the group consisting of histone H2A, histone H2B, histone H3, histone H4, histone H5, penicillin, streptomycin, vancomycin, bacitracin, polymyxin, neomycin, chloramphenicol, chlortetracycline, ciprofloxacin, tobramycin, erythromycin, genamicin, gramicidin, oxytetracycline and norfloxacin, wherein any of the penicillin, streptomycin, vancomycin, bacitracin, polymyxin, neomycin, chloramphenicol, chlortetracycline, ciprofloxacin, tobramycin, erythromycin, genamicin, gramicidin, oxytetracycline and norfloxacin is in a form selected from the group consisting of a salt and an ester.
An antimicrobial composition comprising a eukaryotic histone H1 protein and lysozyme.
A personal care product supplemented with an antimicrobial composition comprising a eukaryotic histone H1 protein.
A medical device comprising an antimicrobial composition comprising a eukaryotic histone 1 protein.
A wrap of synthetic polymer for perishable food, the wrap comprising an antimicrobial composition comprising a eukaryotic histone H1 protein.
Dependencies are inferred from the claim text.