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AssigneeChangchun Institute of Biological Products, Ministry of Public Health
InventorsJingye Liu, Pengfu Wang, Guangpu Li, Baosheng Xie, Zongming Song, Shuyan Li, Jing Liu, Ying Yu, Xizhen Guangpu Zhang, Ben Liang, Lingjiu Liu, Wei Wang, Ling Zhang, Yong Xue, Jing Li, Yuhong Li, Hui Lin, Zongju Wan
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The present invention relates to hepatitis A vaccine, especially to a lyophilized attenuated hepatitis A vaccine which can be stored at ambient temperature for extended periods of time, and to a method for producing the same. The present invention further relates to a stabilizer for lyophilized live vaccine and its use in improving thermostability of lyophilized live vaccine during lyophilization processing and storage period after lyophilization.
A stabilized lyophilized hepatitis A live vaccine formulation comprising prophylactically effective titers of live attenuated hepatitis A virus and a stabilizer, wherein said live attenuated hepatitis A virus is prepared from the wild-type HAV, strain L-A-I, and wherein said stabilizer is present in the vaccine formulation at a concentration sufficient to stabilize the hepatitis A virus against heat inactivation.
A stabilizer for lyophilized live virus, wherein said stabilizer comprises gelatin;
Dependencies are inferred from the claim text.