Stable PQQ-dependent glucose dehydrogenase composition
AssigneeToyo Boseki Kabushiki Kaisha
InventorsShizuo Hattori, Atsushi Sogabe, Seiji Takeshima, Yoshihisa Kawamura
Life of this patent
Estimating the term…
Abstract
The present invention provides a stable lyophilized PQQ-dependent glucose dehydrogenase composition comprising a PQQ-dependent glucose dehydrogenase together with (i) at least one compound selected from the group consisting of aspartic acid, glutamic acid, α-ketoglutaric acid, malic acid, α-ketogluconic acid, α-cyclodextrin and their salts and (ii) an albumin.
Claims14
A stable lyophilized PQQ-dependent glucose dehydrogenase composition consisting essentially of a PQQ-dependent glucose dehydrogenase together with (i) at least one compound selected from the group consisting of α-ketoglutaric acid, malic acid, α-ketogluconic acid, α-cyclodextrin and their salts, (ii) an albumin, (iii) a buffer, and (iv) a calcium ion or a calcium salt.
A method for stabilizing a PQQ-dependent glucose dehydrogenase, said method comprising (a) providing a PQQ-dependent glucose dehydrogenase and (b) forming a lyophilized composition consisting essentially of the PQQ-dependent glucose dehydrogenase together with (i) at least one compound selected from the group consisting of, α-ketoglutaric acid, malic acid, α-ketogluconic acid, α-cyclodextrin and their salts, (ii) an albumin, (iii) a buffer, and (iv) a calcium ion or a calcium salt.
A stable lyophilized PQQ-dependent glucose dehydrogenase composition consisting essentially of a PQQ-dependent glucose dehydrogenase together with (i) at least one compound selected from the group consisting of aspartic acid, α-ketoglutaric acid, malic acid, α-ketogluconic acid, α-cyclodextrin and their salts, (ii) an albumin, (iii) a buffer, and (iv) a calcium ion or a calcium salt.
A method for stabilizing a PQQ-dependent glucose dehydrogenase, said method comprising (a) providing a PQQ-dependent glucose dehydrogenase and (b) forming a lyophilized composition consisting essentially of the PQQ-dependent glucose dehydrogenase together with (i) at least one compound selected from the group consisting of aspartic acid, α-ketoglutaric acid, malic acid, α-ketogluconic acid, α-cyclodextrin and their salts, (ii) an albumin, (iii) a buffer, and (iv) a calcium ion or a calcium salt.
Dependencies are inferred from the claim text.