Drug cartridge assembly and method of manufacture

A method of manufacturing a medical device, comprising:

• separating a glass drug container of the medical device from another component of the medical device;
• sterilizing the glass drug container separately from the other component of the medical device, where the glass drug container is sterilized with a thermal-based sterilization process, and where the other component is sterilized using a radiation-based sterilization process;
• filling the glass drug container with a metered dose of an injectable drug;
• assembling the glass drug container with the other component of the medical device;
• and
• disposing the glass drug container and the other component of the medical device within a sterile package.

A method of manufacturing a sterile injection device, comprising:

• providing a liquid container;
• providing a nozzle sub-assembly, where the liquid container and nozzle-sub-assembly are adapted to be engaged together to enable ejection of liquid from the liquid container out through the nozzle sub-assembly;
• preparing the nozzle sub-assembly for sterilization, where such preparation is performed in a first cleanroom;
• sterilizing the nozzle sub-assembly via irradiation;
• sterilizing the liquid container separately from the nozzle sub-assembly using a thermal sterilization process;
• and
• securing the liquid container and nozzle sub-assembly together, and filling and sealing the liquid container, where the securing, filling and sealing are performed within a second cleanroom, the second cleanroom having a particulate-per-volume rating which is at least ten times lower than that of the first cleanroom.