Device for lysing cells, spores, or microorganisms

A device for use with an ultrasonic transducer to lyse components of a fluid sample, the device comprising:

• a) a cartridge having:
• i) a lysing chamber;
• ii) an inlet port in fluid communication with the lysing chamber;
• and
• iii) an outlet port for exit of the sample from the lysing chamber, wherein the inlet and outlet ports are positioned to permit flow of the sample through the lysing chamber;
• and
• b) at least one solid phase in the lysing chamber for capturing the sample components to be lysed as the sample flows through the chamber;
• wherein the lysing chamber is defined by at least one wall having an external surface to which the ultrasonic transducer may be coupled, and wherein the wall comprises a plastic film having a thickness in the range of 0.01 to 0.5 mm.