Microfluidic devices with thick-film electrochemical detection
AssigneeArrowhead Center, Inc.
InventorsJoseph Wang, Baomin Tian, Eskil Sahlin
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Abstract
An apparatus for conducting a microfluidic process and analysis, including at least one elongated microfluidic channel, fluidic transport means for transport of fluids through the microfluidic channel, and at least one thick-film electrode in fluidic connection with the outlet end of the microfluidic channel. The present invention includes an integrated on-chip combination reaction, separation and thick-film electrochemical detection microsystem, for use in detection of a wide range of analytes, and methods for the use thereof.
Claims82
An apparatus for conducting a microfluidic process and analysis, said apparatus comprising:
- a first substrate having at least one exterior edge;
- at least one elongated separation channel in the first substrate, the separation channel having an inlet end and an outlet end transiting the at least one exterior edge;
- a fluidic transport means for transport of fluids through the separation channel;
- a second substrate;
- and
- at least one thick-film electrode for analyte detection on the second substrate, the thick-film electrode being in fluidic connection with the outlet end of the separation channel.
A method for detecting an analyte, comprising the steps of:
- providing a substrate with a microfluidic channel disposed thereon, the microfluidic channel having an inlet end and an outlet end transiting an exterior edge of the first substrate;
- introducing the analyte in the inlet end of the microfluidic channel;
- transporting the analyte in a fluid solution through the microfluidic channel to the outlet end;
- contacting the solution containing the analyte with a thick-film electrode disposed on a second substrate and in fluidic connection with the outlet end of the microfluidic channel;
- providing electrical contact to the thick-film electrode;
- and
- analyzing the analyte at the thick-film electrode by electrochemical detection.
An apparatus for conducting a microfluidic process and analysis, said apparatus comprising:
- a first substantially planar substrate having at least one defined edge;
- at least one elongated separation channel in the first substrate, the separation channel having an inlet end and an outlet terminating at a defined edge;
- a second substrate with at least one thick-film electrode for analyte detection disposed thereon, the second substrate being removably positionable at a non-zero angle with respect to the first substrate and the thick-film electrode being in fluidic connection with the outlet end of the separation channel.
Dependencies are inferred from the claim text.