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US 6,875,886 B2Granted
Modified PSMA ligands and uses related thereto
AssigneeBeth Israel Deaconess Medical Center, Inc.
InventorJohn V. Frangioni
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Abstract
The instant invention provides reagents and methods for diagnosis, detection and treatment of cancers (for example, prostate cancers). In particular, the invention provides methods to generate various functionalized PSMA ligands, and their uses in diagnosis, detection, imaging, and treatment of prostate cancers, especially those overexpressing PSMA.
Claims47
A compound represented in the formula (II):
- wherein:
- R represents a chelate ligand, a fluorescence tag, or a cytotoxic moiety;
- R3 represents an alkyl, an alkenyl, a cycloalkyl, a cycloalkenyl, an aryl, —(CH2)m-aryl, -alkyl-CO2R4, -alkenyl-CO2R4, -cycloalkyl-CO2R4, -cycloalkenyl-CO2R4 or -aryl-CO2R4;
- R2 and R4, independently for each occurrence, represent hydrogen, a lower alkyl, or a pharmaceutically acceptable salt;
- m is 1, 2, 3 or 4;
- and,
- n is 0, 1, 2 or 3.
4 more elements
Dependencies are inferred from the claim text.