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US 6,875,764 B1Granted
Urea and thiourea compounds useful for treatment of coccidiosis
AssigneeNew Pharma Research Sweden AB
InventorsSabrina Muzi, Shoaá Abdul Rahman
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Abstract
The present invention relates to novel compounds, pharmaceutical compositions containing the same as well as a method for treatment of parasitic disorders, wherein said compounds are administered. The present compounds are especially well suited for treatment of coccidiosis, particularly in poultry, and they have general formula (I): where Y is S or O and R is as defined in the specification.
Claims12
A compound having the general formula (I):
- wherein
- Y is selected from O and S;
- R1 is selected from the group consisting of 4-chloro-3-trifluoromethyl phenyl, N-hexahydrocyclopental[c]pyrrol-2(1H)-yl, 4-methylphenyl, 5-isophthalyl, 6-nitro-1,3-benzothiazol-2-yl, 4-(morpholino)ethyl, 4-cyanophenyl N-3-chloro-2,5,6-trifluoro-4-pyridinyl, 3-chloro-2,5,6-trifluoro-4-pyridinyl, 2,4,5-trihydroxyphenethyl, 3-carboxylphenyl, -3-(1adamantanecarboxylic acid), 2,3-dihydro-1H-inden-5-sulfonyl, 4-chlorophenyl, 3,4,5-trimethoxyphenyl, tetrahydro-2-furanylmethyl, 5-chloro-2-pyridinyl, 5-chloro-2-pyrazinyl, 4-carboxy-3-hydroxy-phenyl, 6-chloro-2-pyrazinyl, 4-fluorophenyl and 1-carboxy-cyclopentyl;
- R2 is selected from the group consisting of (4-fluorophenyl)sulfonyl, (4-nitrophenyl)sulfonyl, 2,2,2-trifluoroethyl, 2-naphtylsulfonyl, 5-bromo-2-pyridinyl, 6-chloro-2-pyrazinyl, and phenyl-sulfonyl;
- R3 is selected from the group consisting of (4-fluorophenyl)sulfonyl, (4-nitrophenyl)sulfonyl, 6-chloro-2-pyrazinyl, 2-naphtylsulfonyl, 5-bromo-2-pyridinyl, 4-cyanophenyl, and phenyl-sulfonyl;
- and
- R4 is selected from the group consisting of 4-nitrophenyl, (4-nitrophenyl)sulfonyl, 4-fluorophenyl, 4-phthalyl, 8-chloro-5-quinolinyl, cyclohexyl, methyl-4-cyclohexancarboxylic acid, phenyl, 3,5-diiodo-4-carboxyphenyl.
4 more elements
Dependencies are inferred from the claim text.