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US 6,875,750 B1Granted
Aziridine compounds and methods of making and using them
AssigneeMax-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
InventorsMarc Pignot, Elmar Weinhold
Life of this patent
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Abstract
Aziridine derivatives of formula (I) are disclosed which can be used as cofactor for S-adenosyl-L-methionine-dependent methyltransferases.
Claims49
A compound of Formula (I):
- wherein Y is N or —CR3, R1 and R3 independently from each other are H, H3, —NH(CH2)nNHR4 or —NH(C2H5O)nC2H5NHR4, with R4 selected from the group consisting of fluorophores, affinity tags, crosslinking agents, chromophors, proteins, peptides, amino acids, nucleotides, nucleosides, nucleic acids, carbohydrates, lipids, PEG, transfection reagents, beads and intercalating agents, and n being an integer from 1 to 250, and R2 is selected from H, 3H, and —CH2CH(COOH)(NH2), provided when R1 is —NH(CH2)nNHR4 or —NH(C2H5O)nC2H5NHR4, Y is N or CH;
- and when R3 is —NH(CH2)nNHR4 or —NH(C2H5O)nC2H5NHR4, R1 is H.
A compound of Formula (II):
- .
A compound of Formula (III):
- .
Dependencies are inferred from the claim text.