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US 6,875,619 B2Granted
Microfluidic devices comprising biochannels
AssigneeMotorola, Inc.
InventorGary Blackburn
Life of this patent
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Abstract
The present invention is directed to a variety of microfluidic devices with configurations including the use of biochannels or microchannels comprising arrays of capture binding ligands to capture target analytes in samples. The invention provides microfluidic cassettes or devices that can be used to effect a number of manipulations on a sample to ultimately result in target analyte detection or quantification.
Claims25
A method of detecting a target analyte in a plurality of samples, said method comprising:
- introducing at least a first sample to a first microchannel;
- introducing at least a second sample to a second microchannel;
- wherein said first and second microchannel each comprise a plurality of spatially distinct regions upon which capture binding ligands are immobilized;
- flowing said first and second sample through said first and second microchannels to form at least one assay complex comprising the target analyte;
- recirculating the flow of at least one sample in at least one microchannel and detecting said target analyte.
2 more elements
A method of detecting a target analyte in a plurality of samples, said method comprising:
- introducing at least a first sample to a first microchannel;
- introducing at least a second sample to a second microchannel;
- wherein said first and second microchannel each comprise a plurality of spatially distinct regions comprising electrodes upon which capture binding ligands are immobilized;
- flowing said first and second sample through said first and second microchannels to form at least one assay complex comprising the target analyte;
- recirculating the flow of at least one sample in least one microchannel;
- and detecting said target analyte.
3 more elements
Dependencies are inferred from the claim text.