Reduced-viscosity concentrated protein formulations
AssigneesGenentech, Inc., Novartis AG
InventorsJun Liu, Steven J. Shire
Life of this patent
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Abstract
The present application concerns concentrated protein formulations with reduced viscosity, which are particularly suitable for subcutaneous administration. The application further concerns a method for reducing the viscosity of concentrated protein formulations.
Claims59
A stable liquid formulation comprising a protein in an amount between about 80 mg/ml to about 130 mg/ml and a salt and/or buffer in an amount of at least about 150 mM and having a kinematic viscosity of about 50 cs or less.
A stable liquid formulation comprising a protein in an amount of between about 80 mg/mi and about 130 mg/ml and a pharmaceutically acceptable acid, base and/or buffer in an amount of at least about 150 mM, so as to have either a pH of about 4.2 to 5.3 or 6.5 to about 12.0 and having a kinematic viscosity of about 50 cs or less.
Dependencies are inferred from the claim text.