Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
AssigneeOsiris Therapeutics, Inc.
InventorsKevin R. McIntosh, Joseph D. Mosca, Elena Klyushnenkova
Life of this patent
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Abstract
A method of reducing an immune response to a transplant in a recipient by treating said recipient with an amount of mesenchymal stem cells effective to reduce or inhibit host rejection of the transplant. The mesenchymal stem cells can be administered before, at the same time as, or after the transplant. Also disclosed is a method of inducing a reduced immune response against a host by foreign tissue, i.e., graft versus host disease, by treatment with mesenchymal stem cells.
Claims20
A process for treating a recipient of a transplant to reduce in said recipient an immune response of effector cells against a xenoantigen to the effector cells, comprising
- administering to a recipient of a transplant mesenchymal stem cells (MSCs) in an amount effective to reduce an immune response of effector cells against a xenoantigen to the effector cells, whereby in the recipient the effector cells have a reduced immune response against the xenoantigen.
Dependencies are inferred from the claim text.