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AssigneesAller Physionix Limited, University of Washington
InventorsPierre D. Mourad, Michel Kliot, Ali Mesiwala, Rex Patterson, Jeffrey G. Jarvik
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Systems and methods for assessment of tissue properties, noninvasively, by acquiring data relating to at least one aspect of intrinsic and/or induced tissue displacement, or associated biological responses, are provided. Data relating to tissue displacement and associated biological changes may be acquired by detecting acoustic properties of tissue using ultrasound interrogation pulses, preferably in a scatter or Doppler detection mode. Based on this data, tissue properties are assessed, characterized and monitored. Specific applications for systems and methods of the present invention include non-invasive assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke, local edema, infection and vasculitus, as well as diagnosis and monitoring of diseases and conditions that are characterized by physical changes in tissue properties. Methods and systems for localizing physiological condition(s) and/or biological response(s), such as pain, by targeting and selectively probing tissues using the application of focused ultrasound are also provided.
A method for detecting a physiological property of a target tissue, comprising:
A method for assessing intracranial pressure (ICP) in a subject, comprising:
A system comprising an acoustic source and an acoustic detector, the acoustic source and detector being operably connected to a power source, the power source being operably connected to a function generator, and the function generator being operably connected to a controller having data acquisition, storage and analysis capability, the controller having the capability to process acquired acoustic data, make determinations of at least one of acoustic emission properties, induced and intrinsic tissue displacements and relate the determination of at least one of acoustic emission properties, induced and intrinsic tissue displacement(s) with at least one physiological tissue condition of a CNS target tissue, the controller being operably connected to a display device for displaying information relating to the at least one physiological tissue condition.
A method for assessing a physiological property of a CNS target tissue, comprising the steps of:
Dependencies are inferred from the claim text.