Method and apparatus for acquiring multidimensional spectra and improved unidimensional spectra within a single scan
AssigneeYeda Research and Development Co. Ltd.
InventorLucio Frydman
Life of this patent
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Abstract
Method and apparatus for treating a sample to acquire multidimensional spectra within a single scan that partitions a sample into a set of independent subensembles endowed with different resonance frequencies. A polychromatic irradiation of the sample is implemented whereby the various subensembles are selectively manipulated by a time-incremented series of excitation or refocusing sequences. Thereafter, a homogeneous sequence capable of generating an observable spectral signal from each of the subensembles is applied with simultaneous monitoring of the observable signals arising from the various subensembles in a resolved fashion the observable signals acquired in this manner are processed into a complete multidimensional spectral data set.
Claims60
A method for treating a sample to acquire multidimensional spectra within a single scan comprising the steps of:
- (1) partitioning a sample into a set of independent subensembles endowed with different resonance frequencies;
- (2) implementing a polychromatic irradiation of the sample whereby the various subensembles are selectively manipulated by a time-incremented series of excitation or refocusing sequences;
- (3) generating an observable spectral signal from each of the subensembles;
- (4) simultaneously monitoring the observable signals arising from the set of subensembles in a resolved fashion;
- (5) processing the observable signals acquired in this manner into a complete multidimensional spectral data set.
A method for treating a sample to acquire multidimensional magnetic resonance spectra within a single scan comprising the steps of:
- (1) applying a magnetic field gradient on the sample so as to endow spins at different positions within the sample with different resonance frequencies;
- (2) applying a train of frequency-selective radiofrequency (RF) pulses in unison with this gradient so as to endow spins at different positions within the sample with incremented values of their evolution times, thus creating an effective spatial encoding of the spins' frequencies (3) creating a set of observable spin signals;
- (4) capturing the signals thus created from the sample while decoding the spins' spatial locations using a second set of acquisition magnetic field gradient;
- (5) subjecting the collected data to a suitable rearrangement and Fourier analysis procedure so as to retrieve the final spectrum being sought.
Apparatus for treating a sample to acquire multidimensional spectra within a single scan comprising (1) means for partitioning a sample into a set of independent subensembles endowed with different resonance frequencies;
- (2) means for implementing a polychromatic irradiation of the sample whereby the various subensembles are selectively manipulated by a time-incremented series of excitation or refocusing sequences;
- (3) means for generating an observable spectral signal from each of the subensembles;
- (4) means for simultaneously monitoring the observable signals arising from the set of subensembles in a resolved fashion;
- and (5) means for processing the observable signals acquired in this manner into a complete multidimensional spectral data set.
Apparatus for treating a sample to acquire multidimensional magnetic resonance spectra within a single scan comprising (1) means for applying a magnetic field gradient on the sample so as to endow spins at different positions within the sample with different resonance frequencies;
- (2) means for applying a train of frequency-selective radiofrequency (RF) pulses in unison with this gradient so as to endow spins at different positions within the sample with incremented values of their evolution times, thus creating an effective spatial encoding of the spins' frequencies (3) means for creating a set of observable spin signals;
- (4) means for capturing the signals, thus created from the sample while decoding the spins' spatial locations using a second set of acquisition magnetic field gradient;
- and (5) means for subjecting the collected data to a suitable rearrangement and Fourier analysis procedure so as to retrieve the final spectrum being sought.
Dependencies are inferred from the claim text.