Benzoquinone ansamycins
AssigneeKosan Biosciences, Inc.
InventorsDaniel Santi, David C. Myles, Zong-Qiang Tian, C. Richard Hutchinson, Robert Johnson, Yi-Qing Zhou, Li Feng
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Abstract
The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.
Claims2
A compound or pharmaceutically acceptable salt thereof having the formula:
- wherein
- R1 is
- R2 is H;
- R3 H;
- R4 Me;
- R5 OH;
- R6 H;
- R7 and R8 taken together form a bond;
- and
- X is a bond.
A compound or pharmaceutically acceptable salt thereof having the formula:
- wherein
- R1 is
- R2 is H;
- R3 is H;
- R4 is Me;
- R5 is OH;
- R6 is H;
- R7 and R8 taken together form a bond;
- and
- X is a bond.
Dependencies are inferred from the claim text.