Method for assessing the risk of peptic ulcer, comprising the steps of determining quantitatively the concentrations of pepsinogen I (PGI) and gastrin-17 in a serum sample

A method for assessing the risk of gastric ulcer comprising

• a. obtaining a serum sample from a patient;
• b. quantitatively measuring the pepsinogen I from said serum sample using an immunoassay and comparing the value obtained to a method-specific reference range of 25-125 μg/l for pepsinogen I;
• and
• c. quantitatively measuring the gastrin-17 from said serum sample using an immunoassay and comparing the value obtained to a gastrin-17 cut -off value of 0.1-2 pmol/l, which overlaps the lower end of the reference range of 2-25 pmol/l for gastrin-17,
• whereby a pepsinogen I concentration in said serum sample above the upper limit of the pepsinogen I reference range and a gastrin-17 concentration within the gastrin-17 reference range or below the gastrin-17 cut-off value is indicative of an increased risk of gastric ulcer.