Pharmaceutical compounds

A compound or its salt having the following general formula (I):

• A—B—C—N(O)2 (I)
• wherein:
• A=R—T1—, wherein
• R is the radical of the drug, as defined hereunder, having the formula R—T1—Z or
• R—T1—OZ in which Z is H or C1-C5 alkyl, selected from the following classes:
• anti-inflammatory drugs:
• acetylsalicylic acid, 5-aminoacetylsalicylic acid, carprofen, diclofenac sodium salt, diflunisal, etodolac, flufenamic acid, flunixin, flurbiprofen, ibuprofen, indomethacin, indoprofen, ketoprofen, ketorolac, lornoxicam, loxoprofen, meclofenamic acid, mefenamic acid, meloxicam, mesalamine, naproxen, niflumic acid, olsalazine, piroxicam, salsalate, sulindac, suprofen, tenoxicam, tiaprofenic acid, tolfenamic acid, tolmetin and zomepirac;
• bronchodilators drugs:
• albuterol, carbuterol, clenbuterol, diphylline, etofylline, fenoterol, metaproterenol, pirbuterol, salmeterol and terbutaline;
• expectorant drugs:
• ambroxol, bromexine and guaiacol;
• antitumoral drugs:
• anthramycin, daunorubicin, doxorubicin and epirubicin;
• antibiotics drugs:
• amoxicillin, ampicillin, aztreonam, biapenem, carbenecillin, cefaclor, cefadroxil, cefamandole, cefatrizine, cefoxitin, dicloxacillin, imipenem, meclocycline, methacycline, moxalactam, panipenem, bacampicillin, apicycline, clomocycline and oxytetracycline;
• bone resorption inhibitors:
• alendronic acid, etidronic acid and pamidronic acid;
• antidementia drugs:
• tacrine;
• T1=(CO), O, S, or NR1C, wherein R1C is H, C1-C5 alkyl, or a free valence;
• B=—TB—X2—TBI wherein
• TB and TBI are equal or different, TB is (CO) when T1 is (CO), O, S, or NR1C, wherein R1C is as above defined, TB is O when T1 is (CO), TBI is (CO) or O;
• X2 is a bivalent bridging group such as the corresponding precursor of B, having the formula Z′—TB—X2TBI—Z″ in which Z′, Z″ are independently H or OH, is selected from the following compounds:
• Hydroxyacids:
• ferulic acid (DII), caffeic acid (DV), hydro caffeic acid (DVI), p-coumaric acid (DVII):
• C is the bivalent —TC—Y— radical, wherein TC is (CO) when TBI is O, TC is O when TBI is (CO);
• Y is a linear or branched (C1-C20)-alkylenoxy group