Biodegradable drug delivery vascular stent
AssigneeSciMed Life Systems, Inc.
InventorsPaul J. Buscemi, Elizabeth A. Stejskal, Donald F. Palme, II, Lixiao Wang
Life of this patent
Estimating the term…
Abstract
A stent includes a main body of a generally tubular shape for insertion into a lumen of a vessel of a living being. The tubular main body includes a substantially biodegradable matrix having collagen IV and laminin that enclose voids within the matrix. The tubular main body also includes a biodegradable strengthening material in contact with the matrix to strengthen the matrix. The tubular main body is essentially saturated with drugs.
Claims20
A method of making a biodegradable stent comprising:
- forming a biodegradable material into a generally tubular main body for insertion into a body lumen of a living being wherein the body lumen has a lumen wall, the tubular main body has an outer surface, and the biodegradable material comprises:
- a substantially biodegradable matrix comprising collagen IV, laminin, and one or more drugs;
- and
- a biodegradable strengthening material in contact with the matrix.
A method of making a biodegradable stent comprising:
- forming a biodegradable material by contacting a substantially biodegradable matrix with a biodegradable strengthening material to strengthen the matrix, wherein the biodegradable strengthening material includes a plurality of microcapsules containing a material capable of inducing crosslinking of the biodegradable strengthening material;
- forming the biodegradable material into a generally tubular main body in the form of a coiled strip for insertion into a lumen of a vessel;
- applying energy to the biodegradable material, wherein the application of energy causes a rupture of the microcapsules and a release of the material inducing crosslinking of the biodegradable strengthening material.
A biodegradable stent made by the process comprising:
- forming a biodegradable material into a generally tubular main body for insertion into a body lumen of a living being, wherein the tubular main body has an outer surface, and the biodegradable material comprises:
- a substantially biodegradable matrix comprising collagen IV, laminin, and a drug;
- and
- a biodegradable strengthening material in contact with the matrix to strengthen the matrix.
Dependencies are inferred from the claim text.