Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages

An oligomeric compound of the formula:

• 5′-(Nu1—L1)n—Y—(L2-Nu2)p—3′
• wherein:
• each Nu1 and Nu2, independently, has the formula:
• wherein
• Bx is a heterocyclic base moiety;
• Lx is hydrogen, a protecting group or a substituent group;
• one of R12, R13 and R14 is hydroxyl, a protected hydroxyl, a covalent attachment to a solid support, a nucleoside, an oligonucleoside, a nucleotide, an oligonucleotide, a conjugate group or an optionally protected substituent group;
• another of R12, R13 and R14 is hydrogen, hydroxyl, a protected hydroxyl or an optionally protected substituent group;
• the remaining of R12, R13 and R14, of Nu1, is L1;
• the remaining of R12, R13 and R14, of Nu2, is L2;
• each L1 and each L2 is, independently, a phosphodiester, phosphorodithioate;
• chiral Sp phosphorothioate;
• phosphoramidate;
• thiophosphoramidate;
• phosphonate;
• methylene phosphonate;
• phosphotriesters;
• thionoalkylphosphonate;
• thionoalkylphosphotriester;
• boranophosphate;
• boranothiophosphate;
• thiodiester;
• thionocarbamate;
• siloxane;
• carbamate;
• sulfamate;
• morpholino sulfamide;
• sulfonamide;
• sulfide;
• sulfonate;
• N,N′-dimethylhvdrazine;
• thioformacetal;
• formacetal;
• thioketal;
• ketal;
• amine (—NH—CH2—CH2—);
• hydroxylamine;
• hydroxylimine;
• hydrazinyl;
• amide (—CH2—N(JJ)—C(O)—) and (—CH2—C(O)—N(JJ)—);
• oxime (—CH2—O—N═CH—);
• or alkylphosphorus (—C(JJ)2—P(═O)(OJJ)—C(JJ)2—C(JJ)2—) internucleoside linkage, wherein each JJ is, independently, hydrogen or C1 to C10 alkyl wherein at least one of L1 and L2 is other than phosphodiester;
• Y has the formula:
• wherein;
• each Rp is a chiral Rp phosphorothioate internucleotide linkage;
• and
• each n, m and p is, independently, from 1 to 100;
• where the sum of n, m and p is from 3 to about 200;
• wherein the oligomeric compound comprises from 5 to about 50 nucleosides.