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US 6,864,239 B2Granted
Methods and compounds for prevention and treatment of elevated intraocular pressure and related conditions
AssigneeTheratechnologies Inc.
InventorsKrishna G. Peri, Serge Moffett, Daniel Abran
Life of this patent
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Abstract
A GPCR-like protein is described, as well as inhibitory/antagonistic compounds and compositions comprising such inhibitors/antagonists of the protein. Such compounds may be used for treating elevated intraocular pressure and conditions associated with elevated intraocular pressure, such as glaucoma.
Claims29
A substantially pure peptide compound of Formula I:
- Z1-Ile-Phe-Asp-Ser-Thr-Glu-Cys-Trp-Z2 I
- wherein:
- Z1 is an N-terminal group of the formula H2N—, RHN— or, RRN—;
- Z2 is a C-terminal group of the formula —C(O)OH, —C(O)R, —C(O)OR, —C(O)NHR, —C(O)NRR;
- R at each occurrence is independently selected from (C1-C6) alkyl, (C1-C6) alkenyl, (C1-C6) alkynyl, substituted (C1-C6) alkyl, substituted (C1-C6) alkenyl, or substituted (C1-C6) alkynyl;
- and “—” is a covalent linkage.
3 more elements
A substantially pure synthetic peptide compound or recombinant peptide compound, said compound having a domain of Formula II:
- -Ile-Phe-Asp-Ser-Thr-Glu-Cys-Trp- II
- wherein
- “—” is a covalent linkage.
Dependencies are inferred from the claim text.