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US 6,864,082 B2Granted
Modified viral surface proteins for binding to extracellular matrix components
AssigneeUniversity of Southern California
InventorsFrederick L. Hall, Erlinda Maria Gordon, W. French Anderson, Vaughn A. Starnes
Life of this patent
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Abstract
A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds to an extracellular matrix component. Such vector particles are useful in delivering genes encoding therapeutic agents to cells located at the site of an exposed extracellular matrix component.
Claims2
A modified retroviral envelope polypeptide comprising SEQ ID NO:
- 1 wherein SEQ ID NO:3 inserted between amino acid residues 18 and 19 of SEQ ID NO:1.
Dependencies are inferred from the claim text.