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US 6,863,899 B2Granted
Composite shaped bodies and methods for their production and use
AssigneeVita Special Purpose Corporation
InventorsAntony Koblish, Ronald Sapieszko, David Dychala, Erik Erbe
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Abstract
Shaped, composite bodies are provided. One portion of the shaped bodies comprises an RPR-derived porous inorganic material, preferably a calcium phosphate. Another portion of the composite bodies is a different solid material, preferably metal, glass, ceramic or polymeric. The shaped bodies are especially suitable for orthopaedic and other surgical use.
Claims9
A shaped body comprising:
- a first segment comprising a polymerizable matrix and an inorganic filler;
- and in contact with at least a portion of the first segment, a second segment comprising calcium phosphate having substantially uniform macro-, meso- and microporosity together with a pore volume of at least about 30%. phosphate.
A composite body having at least two portions:
- a first portion comprising the oxidation-reaction product of a blend comprising
- at least one metal cation;
- at least one oxidizing agent;
- and
- at least one precursor anion oxidizable by said oxidizing agent to form an oxoanion;
- the second portion being imbibed into the first portion wherein the second portion is selected from the group consisting of polycaprolactones, polyglycolic acid, poly-L-lactic acid, polysulfones, polyolefins, polyvinyl alcohol, polyalkenoics, polyacrylic acids, and polyesters.
3 more elements
A composite body for drug delivery comprising:
- a first portion comprising the oxidation-reaction product of a blend comprising
- at least one metal cation;
- at least one oxidizing agent;
- and
- at least one precursor anion oxidizable by said oxidizing agent to form an oxoanion;
- a second, resorbable portion imbibed into the first portion;
- and
- a medicament, medicament is a growth hormone, antibiotic material, proteins, cell signaling material, steroids, analgesics, or fertility drugs.
5 more elements
A shaped body comprising:
- a first portion comprised of an inorganic material having substantially uniform macro-, meso- and microporosity together with a pore volume of at least about 30%;
- and
- a second portion that contacts at least a portion of the first portion, wherein the second portion is a powder comprises L-Iactic acids comprised of a powder.
Dependencies are inferred from the claim text.