US 6,862,890 B2 · Process for production of nanoparticles and microparticles by spray freezing into liquid

Abstract

The present invention provides a system and a method for the production of microparticles and nanoparticles of materials that can be dissolved. The system and method of the present invention provide quicker freezing times, which in turn produces a more uniform distribution of particle sizes, smaller particles, particles with increased porosity and a more intimate mixing of the particle components. The system and method of the present invention also produce particles with greater surface area than conventional methods. One form of the present invention provides a method for the preparation of particles. An effective ingredient is mixed with water, one or more solvents, or a combination thereof, and the resulting mixture is sprayed through an insulating nozzle located at or below the level of a cryogenic liquid. The spray generates frozen particles.

Claims14

Dependent claims

A system for preparing particles comprising:

a solution source comprising an effective ingredient;
a vessel containing a cryogenic liquid selected from the group consisting of carbon dioxide, nitrogen, ethane, propane, helium, argon, or isopentane;
and
an insulating nozzle having an end and a tip, wherein the end of the insulating nozzle is connected to the solution source and the tip is placed at or below the level of the cryogenic liquid.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

10/062,648Filed 30 Jan 2002 · us provisional application

Priority

30 Jan 2001

Published

US 2003/0041602 A16 Mar 2003

Granted

8 Mar 2005

Term ends

Not estimatedThe source records don’t support an estimate.

Classification25 codes

F26B 5/065
The process involving freezing: the product to be freeze-dried being sprayed, dispersed or pulverised
A61K 9/1617
Excipients; Inactive ingredients: organic compounds, e.g. phospholipids, fats
A61K 9/1623
Organic compounds, e.g. phospholipids, fats: sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
A61K 9/1635
Organic macromolecular compounds: obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, polyacrylates

Process for production of nanoparticles and microparticles by spray freezing into liquid

Life of this patent

Process for production of nanoparticles and microparticles by spray freezing into liquid

Life of this patent

Abstract

Claims14