# US 6,862,469 B2 · Method for combining proton beam irradiation and magnetic resonance imaging > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 6,862,469 B2 - Document ID: US6862469B2 - Status: Granted - Kind: B2 - Application number: 10/826,436 - Filed: 2004-04-16 - Published: 2004-10-07 - Granted: 2005-03-01 - Earliest claimed: 2000-01-31 - Assignees: St. Louis University - Inventors: Richard D. Bucholz; D. Douglas Miller - Web page: https://patentgrep.com/patent/US6862469B2 ## CPC - A61N 5/1049: {for verifying the position of the patient with respect to the radiation beam} - A61B 5/055: involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging - A61B 5/704: {Tables} - A61N 5/1037: {taking into account the movement of the target, e.g. 4D-image based planning} - A61N 5/1064: {for adjusting radiation treatment in response to monitoring} - A61N 5/1067: {in real time, i.e. during treatment} - A61N 5/107: {in real time, i.e. during treatment} - A61N 2005/1055: {using magnetic resonance imaging [MRI]} - A61N 2005/1087: {Ions; Protons} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A method which coordinates proton beam irradiation with an open magnetic resonance imaging (MRI) unit to achieve near-simultaneous, noninvasive localization and radiotherapy of various cell lines in various anatomic locations. A reference image of the target aids in determining a treatment plan and repositioning the patient within the MRI unit for later treatments. The patient is located within the MRI unit so that the target and the proton beam are coincident. MRI monitors the location of the target. Target irradiation occurs when the target and the proton beam are coincident as indicated by the MRI monitoring. The patient rotates relative to the radiation source. The target again undergoes monitoring and selective irradiation. The rotation and selective irradiation during MRI monitoring repeats according to the treatment plan. ## Claims ### Claim 1 A method for treating a target within a body of a patient, said method comprising: irradiating a treatment volume having a known position; supporting the patient such that the target is adjacent to the treatment volume; scanning the body to monitor the position of the target; selectively activating a radiating apparatus in response to the monitored position of the target to irradiate the target when the target is at least partially coincident with the treatment volume; and selectively deactivating the radiating apparatus in response to the monitored position of the target when the target is not at least partially coincident with the treatment volume. ### Claim 2 (depends on 1) The method of claim 1 wherein said supporting the patient includes adjusting an upright supporting mechanism supporting the patient so that the target is at least partially coincident with the treatment volume. ### Claim 3 (depends on 2) The method of claim 2 wherein said supporting the patient further includes adjusting a platform supporting the patient so that the target is at least partially coincident with the treatment volume. ### Claim 4 (depends on 3) The method of claim 3 wherein said supporting the patient further includes adjusting the position of the patient so that the target is at least partially coincident with the treatment volume. ### Claim 5 (depends on 4) The method of claim 4 wherein said supporting the patient further includes moving the patient so that the target is located along a line as defined by the radiating apparatus and the treatment volume. ### Claim 6 (depends on 5) The method of claim 5 wherein said supporting the patient further includes attenuating the irradiating so that the treatment volume is at least partially coincident with the target. ### Claim 7 (depends on 1) The method of claim 1 further comprising rotating the patient relative to the radiating apparatus and again selectively irradiating the treatment volume in the adjusted position. ### Claim 8 (depends on 1) The method of claim 1 further comprising rotating the patient relative to the radiating apparatus by rotating the patient relative to the target. ### Claim 9 (depends on 1) The method of claim 1 further comprising rotating the patient relative to the radiating apparatus by rotating the radiating apparatus relative to the treatment volume. ### Claim 10 A method for treating a target within a body of a patient with a proton beam radiating apparatus having a Bragg peak irradiating a treatment volume having a known position, said method comprising: positioning the patient such that the target to be treated is located near the treatment volume; scanning the body to determine the position of the target relative to the treatment volume; activating the proton beam radiating apparatus to irradiate the target when the determined position of the target is at least partially coincident with the known position of the treatment volume; and deactivating the proton beam radiating apparatus when the determined position of the target is not at least partially coincident with the treatment volume. ### Claim 11 (depends on 10) The method of claim 10 wherein said positioning the patient includes adjusting an upright supporting mechanism supporting the patient so that the target is at least partially coincident with the treatment volume. ### Claim 12 (depends on 11) The method of claim 11 wherein said supporting the patient further includes adjusting a platform supporting the patient so that the target is at least partially coincident with the treatment volume. ### Claim 13 (depends on 12) The method of claim 12 wherein said supporting the patient further includes adjusting the position of the patient so that the target is at least partially coincident with the treatment volume. ### Claim 14 (depends on 13) The method of claim 13 wherein said supporting the patient further includes moving the patient so that the target is located along a line as defined by the radiating apparatus and the treatment volume. ### Claim 15 (depends on 14) The method of claim 14 wherein said supporting the patient further includes attenuating the irradiating so that the treatment volume is at least partially coincident with the target. ### Claim 16 (depends on 10) The method of claim 10 further comprising rotating the patient relative to the radiating apparatus and again irradiating the treatment volume in the adjusted position. ### Claim 17 (depends on 10) The method of claim 10 further comprising rotating the patient relative to the radiating apparatus by rotating the patient relative to the target.