Compounds and methods for the modulation of CD154
AssigneesCbr, Millenium Pharmaceuticals, Inc.
InventorsDavid Phillips, Patrick Andre, Denisa D. Wagner
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Abstract
The present invention relates to compounds that are capable of modulating CD154 mobilization and that are useful for stabilizing the thrombotic process and reducing the activation of cells involved in an inflammatory response. The present invention also relates to methods useful for identifying such compounds. The present invention also relates to the treatment of platelets for transfusion with metalloproteinase inhibitors to treat or prevent inflammation. The present invention also includes compositions and methods to treat injury and disease related to such biological processes.
Claims7
A method for the treatment of thrombosis in a subject comprising:
- administrating a CD154 inhibitor in an amount effective to inhibit the release of soluble CD154 (sCD154) from a platelet.
Dependencies are inferred from the claim text.