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US 6,858,602 B2Granted
Compounds for the treatment of metabolic disorders
AssigneeWellstat Therapeutics Corporation
InventorsShalini Sharma, Reid W. von Borstel
Life of this patent
Estimating the term…
Abstract
Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
Claims9
A compound of the formula:
- wherein
- n is 1 or 2;
- m is 0 or 1;
- q is 0 or 1;
- t is 0 or 1;
- R5 is alkyl having from 1 to 3 carbon atoms;
- and
- R9 is hydrogen;
- and
- X is —CH2CR12R13— wherein one of R12 and R13 is hydrogen or methyl and the other is methyl, Q is OR1 and R1 is hydrogen or alkyl having from 1 to 7 carbon atoms;
- or X is —CH2CH2— and Q is NR10R11 wherein one of R10 and R11 is hydrogen, alkyl having from 1 to 3 carbon atoms or hydroxy, and the other is hydrogen or alkyl having from 1 to 3 carbon atoms;
- or
- R9 is halo, or alkoxy having from 1 to 3 carbon atoms;
- and
- X is —CH2—, Q is —OR1 and R1 is ethyl;
- or X is —CH2CR12R13— or —CH2CH(NHAc)— wherein each of R12 and R13 is independently hydrogen or methyl, Q is OR1 and R1 is hydrogen or alkyl having from 1 to 7 carbon atoms;
- or X is —CH2CH2— and Q is NR10R11 wherein one of R10 and R11 is hydrogen, alkyl having from 1 to 3 carbon atoms or hydroxy, and the other is hydrogen or alkyl having from 1 to 3 carbon atoms;
- and
- A is a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of formula I′ by a ring carbon;
- or when R1 is hydrogen, a pharmaceutically acceptable salt of the compound.
17 more elements
A compound of the formula:
- wherein
- n is 1 or 2;
- m is 0 or 1;
- q is 0 or 1;
- t is 0 or 1;
- R5 is alkyl having from 1 to 3 carbon atoms;
- A is a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of formula I by a ring carbon;
- and
- X is —CH2— and R1 is ethyl;
- or X is —CH2CH2— or —CH2CH(NHAc)— and R1 is hydrogen or alkyl having from 1 to 7 carbon atoms;
- or when R1 is hydrogen, a pharmaceutically acceptable salt of the compound.
8 more elements
Dependencies are inferred from the claim text.