Fabrication of drug loaded biodegradable polymer fibers
AssigneeBoard of Regents, The University of Texas System
InventorsKevin D Nelson, Andres A. Romero-Sanchez, George M. Smith, Nadir Alikacem, Delia Radulescu, Paula Waggoner, Zhibing Hu
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Abstract
The invention provides tissue engineering compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The matrices comprise biodegradable polymer fibers capable of the controlled delivery of therapeutic agents. The spatial and temporal distribution of released therapeutic agents is controlled by use of defined nonhomogeneous patterns of therapeutic agents in the matrices.
Claims23
A method of extruding a drug releasing fiber from chitosan comprising use of hydrochloric acid as a solvent and Tris base as coagulating bath.
A method of creating a drug releasing fiber from chitosan, said method comprising:
- a) obtaining a polymer solution comprising chitosan and a hydrochloric acid;
- and
- b) extruding the polymer solution into a coagulating bath comprising tris base.
Dependencies are inferred from the claim text.