Inhibitors of α4 mediated cell adhesion

A compound of formula [III]:

• wherein:
• n is an integer of 1;
• W is a —CH═CH— group;
• R4a is an ester group;
• R5 is hydrogen atom, or a substituted or unsubstituted lower alkyl group;
• R6 is a phenyl group which has 2-5 substituents selected from the group consisting of:
• a) a halogen atom,
• b) a formyl group,
• c) a hydroxyl group,
• d) a lower alkoxy group which may be substituted by 1) a carboxy group, 2) a hydroxyl group, 3) a cyano group, 4) a halogen atom, 5) an amino group which may be substituted by a lower alkyl group, 6) a pyridyl group, 7) a phenyl group, 8) a thienyl group, or 9) a lower alkoxy group,
• e) a lower alkyl group which may be substituted by 1) an amino group which may be substituted by a lower alkyl group, a hydroxy-lower alkyl group, a (lower alkylamino)-lower alkyl group or a phenyl group, 2) a piperidinyl group which may be substituted by a lower alkylenedioxy group, 3) a morpholino group which may be substituted by a lower alkyl group, 4) a thiomorpholino group in which sulfur atom may be oxidized, 5) a piperazinyl group which may be substituted by a lower alkyl group, a hydroxyl-lower alky group, a lower alkanoyl group or a phenyl-lower alkyl group, 6) a pyrrolidinyl group, which may be substituted by oxo group, or 7) an imidazolidinyl group which may be substituted by 1-3 groups selected from the group consisting of a lower alkyl group and oxo group,
• f) an amino group which may be substituted by 1) a lower alkoxycarbonyl group, 2) a lower alkanesulfonyl group, 3) a carbamoyl group which may be substituted by a lower alkyl group, or a lower alkyl-phenyl group, 4) a lower alkanoyl group, 5) a lower alkyl group,6) a lower alkenyl group, or 7) a thiocarbamoyl group which may be substituted by a lower alkyl group,
• g) a carbamoyl group which may be substituted by 1) a lower alkyl group, 2) a hydroxy-lower alkyl group, 3) a morpholino-lower alkyl group, 4) a phenyl-lower alkyl group, or 5) a lower alkanesulfonyl group,
• h) a sulfamoyl group which may be substituted by a lower alkyl group,
• i) a lower alkenyloxy group,
• j) a lower alkylenedioxy group,
• k) a cyano group,
• l) a lower alkylthio group, and
• m) a lower alkanesulfonyl group,
• or a salt thereof.