Allomorph of isomer Z hydrochloride of alkylaminofurane derivative
AssigneePharmexcel SRL
InventorPaolo Alberto Veronesi
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Abstract
Allomorph of Z isomer of N-[2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethyl]-N′-methyl-2-nitro-1,1-ethenediamine hydrochloride, with two carbon atoms linked by a rigid ethylenic bond, marked by an asterisk (*), characterized by the following structural formula: wherein -Fur- represents a furane ring.
Claims9
Allomorph of Z isomer of N-[2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethyl]-N′-methyl-2-nitro-1,1-ethenediamine hydrochloride, with two carbon atoms linked by a rigid ethylenic bond, marked by an asterisk (*), characterized by the following structural formula:
- wherein -Fur- represents a furane ring.
Preparation process of allomorph (A) of Z isomer of N-[2-[[[5-(dimethylamino)methyl-2-furanyl]methyl] thio]ethyl]-N′-methyl-2-nitro-1,1-ethenediamine hydrochloride, characterized by the reaction of Z, N-[2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethyl]-N′-methyl-2-nitro-1,1-ethenediamine, suspended in anhydrous ethyl acetate, with a solution of hydrochloric acid in anhydrous isopropanol, added dropwise by keeping the reaction mixture at room temperature.
Procedure for the preparation of allomorph (B) of Z isomer of N-[2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethyl]-N′-methyl-2-nitro-1,1-ethenediamine hydrochloride, characterized by the reaction of Z, N-[2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio] ethyl]-N′-methyl-2-nitro-1,1-ethenediamine, suspended in ethyl acetate, with a solution of hydrochloric acid in isopropanol with 3% of water, added dropwise to the previous one by keeping the reaction mixture at room temperature.
Dependencies are inferred from the claim text.