Process for the preparation of pure citalopram
AssigneeH. Lundbeck A/S
InventorsAndrea Castellin, Giulio Volpe, Federico Sbrogiò
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Abstract
A process for the preparation of citalopram of formula (I) in which a compound of formula (II) wherein Z is iodo, bromo, chloro or CF3—(CF2)n—SO2—O— n being 0, 1, 2, 3, 4, 5, 6, 7 or 8, is subjected to a cyanide exchange reaction in which the group Z is exchanged with cyanide by reaction with a cyanide source; the resultant crude citalopram product is optionally subjected to some initial purification and the crude citalopram base is subsequently subjected to a film distillation process; the resulting citalopram product is then optionally further purified and worked up and isolated as the base or a pharmaceutically acceptable salt thereof.
Claims14
A process for the preparation of citalopram of formula I
- in which 1 a compound of formula II
- wherein Z is iodo, bromo, chloro or CF3—(CF2)n—SO2—O—;
- and
- n is 0, 1, 2, 3, 4, 5, 6, 7 or 8;
- is subjected to a cyanide exchange reaction in which the group Z is exchanged with cyanide by reaction with a cyanide source;
- the resultant crude citalopram product is optionally subjected to some initial purification and the crude citalopram base is subsequently subjected to a film distillation process,
- the resulting citalopram product is then optionally further purified, and worked up and 2 isolated as the product or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.