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US 6,855,833 B2Granted
Methods for producing amino substituted chromanes and intermediates thereof
AssigneeMillennium Pharmaceuticals, Inc.
InventorsJames Kanter, John J. G. Mullins, Robert Scarborough, Derek Walker, Thomas Hense
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Abstract
Disclosed are processes for producing chromane compounds, preferably chroman-2-yl acetic acid compounds and 6-amino-chroman-2-yl acetic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors.
Claims21
A process for making a compound according to the formula
- wherein R is H or an alkyl group, and R1 is an amino group, an amino with a protecting group, or a nitro group, comprising:
- (a) reacting a compound of the formula:
- with a base under anhydrous conditions followed by adding a proton donor to produce a 2-hydroxy chromane compound of the formula:
- (b) condensing the hydroxychromane compound of (a) with a nucleophilic carbon species to afford the acetate compound as follows:
1 more element
Dependencies are inferred from the claim text.