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US 6,855,830 B2Granted
Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
AssigneeGenzyme Corporation
InventorsBradford H. Hirth, Craig Siegel
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Abstract
Disclosed is a novel enantiomeric synthesis cermamide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
Claims2
A compound represented by the following structural formula:
- the enantiomer of the compound, a salt of the compound, or
- a salt of the enantiomer, wherein:
- R4 is H2 or O;
- and
- R6 is represented by the following structural formula:
- wherein phenyl ring A is substituted or unsubstituted;
- or
- when R4 is H2, R6 can further be —H.
5 more elements
Dependencies are inferred from the claim text.