Peptides modulating activities of heparin other glycosaminoglycans or proteoglycans
AssigneeThomas Jefferson University
InventorsJames D. San Antonio, Angela Verrecchio, Barbara P. Schick
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Abstract
The present invention involves peptides of various sequences and sizes and methods of using said peptides with a strong affinity for glycosaminoglycans and proteoglycans, wherein said peptides interact strongly with heparin, other glycosaminoglycans, or proteoglycans (PGs).
Claims13
A synthetic peptide with a high affinity for glycosaminoglycans and proteoglycans of a formula selected from the group consisting of (XBBBXXBX)n, (XBXXBBBX)n, (XBBXBX)n, and (XBXBBX)n, wherein:
- each B is independently selected from the group consisting of arginine and lysine residues;
- each X is independently any amino acid residue;
- and
- n is at least 2.
A synthetic peptide of a formula selected from the group consisting of (XBBBXXBX)n, (XBXXBBBX)n, (XBBXBX)n, and (XBXBBX)n, wherein:
- each B is independently selected from the group consisting of arginine and lysine residues;
- each X is independently any amino acid residue;
- n is at least 2;
- provided that a single cysteine residue is contained in said synthetic peptide at an X position within three amino acid residues of the N-terminus or the C-terminus of said synthetic peptide.
A synthetic concatameric peptide with a high affinity for glycosaminoglycans and proteoglycans wherein the sequence of amino acid residues of said peptide is represented by at least two segments selected from the group consisting of XBBBXXBX, XBXXBBBX, XBBXBX, and XBXBBX, wherein:
- said peptide does not comprise only XBBBXXBX segments;
- said peptide does not comprise only XBXXBBBX segments;
- said peptide does not comprise only XBBXBX segments;
- said peptide does not comprise only XBXBBX segments;
- each segment is separated from an adjacent segment by at least one of any amino acid residue;
- each B is independently selected from the group consisting of arginine and lysine residues;
- and
- each X is independently selected from the group consisting of cysteine, alanine and glycine residues, provided that a single cysteine residue is contained in said synthetic peptide at an X position within three amino acid residues of the N-terminus or the C-terminus of said synthetic peptide.
Dependencies are inferred from the claim text.