Tropane derivatives useful in therapy

A compound of formula (I)

• or a pharmaceutically acceptable salt or solvate thereof wherein:
• X and Y are selected from CH2 and NR4 such that one of X and Y is CH2 and the other is NR4;
• R1 and R4 are independently R5;
• COR5;
• CO2R5;
• CONR6R7;
• SO2R5;
• or (C1-6 alkylene)phenyl, wherein phenyl is substituted by 0 to 3 atoms or groups selected from C1-6 alkyl, C1-6 alkylcarbonyl, C1-6 alkoxy, C1-6 alkoxycarbonyl, halogen, CF3, OH, CN, NR6R7, COR7, CO2R7 or CONR6R7;
• R2 is phenyl substituted by 0 to 3 atoms or groups selected from C1-6 alkyl, C1-6 alkylcarbonyl, C1-6 alkoxy, C1-6 alkoxycarbonyl, halogen, CF3, OH, CN, NR6R7, CO2R7 or CONR6R7;
• R3 is C1-4 alkyl substituted by 0 to 3 fluorine atoms;
• R5 is C1-6 alkyl;
• C2-6 alkenyl;
• C2-6 alkynyl;
• C3-7 cycloalkyl;
• a 5 or 6-membered aromatic heterocycle;
• or a 4 to 7-membered saturated heterocycle;
• wherein said alkyl, alkenyl, alkynyl and cycloalkyl are substituted by 0 to 3 atoms or groups selected from oxo, halogen, CF3, OR7, CN, NR6R7, COR7, CO2R7 or CONR6R7;
• wherein said heterocycles contain one to three heteroatoms selected from N, O or S;
• and wherein said heterocycles are substituted by 0 to 3 atoms or groups selected from C1-6 alkyl, C1-6 alkylcarbonyl, C1-6 alkoxy, C1-6 alkoxycarbonyl, halogen, CF3, OH, CN, NR6R7, COR7, CO2R7 or CONR6R7;
• R6 is H;
• C1-6 alkyl;
• C2-6alkenyl ;
• C2-6 alkynyl;
• C3-7 cycloalkyl;
• a 5 or 6-membered aromatic heterocycle;
• or a 4 to 7-membered saturated heterocycle;
• wherein said alkyl, alkenyl, alkynyl and cycloalkyl are substituted by 0 to 3 atoms or groups selected from oxo, halogen, CF3, OR7, CN, COR7 or CO2R7;
• wherein said heterocycles contain one to three heteroatoms selected from N, O or S;
• and wherein said heterocycles are substituted by 0 to 3 atoms or groups selected from C1-6 alkyl, C1-6 alkylcarbonyl, C1-6 alkoxy, C1-6 alkoxycarbonyl, halogen, CF3, OH, CN, COR7 or CO2R7;
• R7 is H or C1-6 alkyl;
• or, when R6 and R7 are both attached to the same N atom, NR5R7 may also represent a 5 to 7 membered, saturated, partially unsaturated or aromatic, heterocycle containing from 0 to 2 additional heteroatoms selected from O, N or S.