Substituted indoles and their use as integrin antagonists

A compound having the Formula IV:

• wherein:
• R1, R2, R3, R4 and R5 independently represent hydrogen, halogen, akyl, aryl, aralkyl, heteroaryl or heteroarylalkyl;
• R6, R7, R8 and R9 independently represent hydrogen, alkyl, hydroxyalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, carboxyalkyl, aryl or aralkyl;
• or R6 and R7 are taken together to form —(CH2)p—, where p is 2-8, while R8 and R9 are defined as above;
• or R8 and R9 are taken together to form —(CH2)q—, where q is 2-8, while R6 and R7 are defined as above;
• or R6 and R8 are taken together to form —(CH2)r—, while r is zero (a bond), 1 or 2, while R7 and R9 are defined as above;
• X represents oxygen, sulfur, —CH2—, —NH—, —(C═O)NH— or —NH(C═O)—;
• n is from 0 to 4;
• m is from 0 to 4;
• a is 0 or 1;
• D represents oxygen;
• v is 0 or 1;
• R10, R11, R12 and R13 independently represent:
• hydrogen;
• hydroxy;
• alkyl;
• alkoxy;
• cycloalkyl;
• aryl, optionally substituted with one or more of halogen, hydroxy, cyano, alkyl, aryl, alkoxy, haloalkyl, arylalkyl, arylalkoxy, aryloxy, alkylsulfonyl, alkylsulfinyl, alkylalcoxyaryl, monoalkylamino, dialkylamino, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, alkanoyl;
• monoalkylamino;
• dialkylamino;
• aminoalkyl;
• monoalkylaminoalkyl;
• dialkylaminoalkyl;
• alkanoyl;
• heteroaryl having 5-14 ring members, optionally substituted with one or more of halogen, hydroxy, cyano, alkyl, aryl, alkoxy, haloalkyl, arylalkyl, arylalkoxy, aryloxy, alkylsulfonyl, alkylsulfinyl, alkylalkoxyaryl, monoalkylamino, dialkylamino, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, alkanoyl;
• or
• wherein R17 and R18 together form —CH2CH2—O—, —O—CH2CH2—, —O—CH2—O— or —O—CH2CH2—O—;
• or
• R10 and R12 are taken together to form —(CH2)s—, wherein s is 0 (a bond) or 1 to 4, while R11 and R13 are as defined as above;
• or R10 and R12 are taken together to form a double bond when i is 0 and k is 1, while R11 and R13 are as defined above;
• or R10 and R11 are taken together to form —(CH2)t—, wherein t is 2 to 8, while R12 and R13 are as defined as above, or
• R12 and R13 are taken together to form —(CH2)u— wherein u is 2 to 8, while R10 and R11 are as defined as above;
• i is from 0 to 4;
• j is from 0 to 4;
• k is 0 or 1;
• R14 is hydrogen, alkyl, aryl, aralkyl, dialkylaminoalkyl, 1-morpholinoalkyl, 1-piperidinylalkyl, pyridinylalkyl, alkoxy(alkoxy) alkoxyalkyl, or (alkoxycarbonyl)oxyethyl;
• W is:
• wherein:
• R16 is hydrogen, alkyl, haloalkyl or halogen;
• and
• R27, R28, and R29 are independently hydrogen, halogen, alkyl, alkoxy or aryl.