Methods and compositions for alleviating stuttering
AssigneeIndevus Pharmaceuticals, Inc.
InventorsJohn J. Murphy, Kay Jorgenson D'Orlando
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Abstract
Methods of treating stuttering include treating people with gamma-aminobutyric acid (GABA) receptor modulators, including cyclopyrrolones. A second active agent may be used with GABA receptor modulators. Active enantiomers, active metabolites, and pharmaceutically acceptable salts of gamma-aminobutyric acid receptor modulators, including cyclopyrrolones, are acceptable components of the compositions. The cyclopyrrolone class of modulators includes pagoclone, suriclone, zopiclone, 2-(7-chloro-2-naphthyridin-1,8-yl)-3-(5-methyl-2-oxohexyl)isoindolin-1-one, 2-(7-chloro-2-naphthyridin-1,8-yl)isoindolin-1-yl-4-acetamidobutyrate, and 2-(7-chloro-1,8-naphthyridin-2y1)-3-(5-methyl-5-hydroxy-2-oxohexyl)-1-isoindolinone.
Claims1
A method of alleviating stuttering in a subject in need thereof, the method comprising administering a therapeutically effective dose of pagoclone or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.