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US 6,855,712 B2Granted
Combination of benzoquinazoline antifolates and protecting agents
AssigneeSmithKline Beecham Corporation
InventorsGary Keith Smith, David Stanley Duch, Robert Ferone, Arthur Koch
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Abstract
The use of a protecting agent, for example a folate derivative such as folic acid or leucovorin, in combination with a non-competitive folic acid analogue, for example benzoquinazoline derivatives, for use in reducing the side effects associated with the administration of such non-competitive folic acid analogues, and pharmaceutical formulations comprising such combinations are disclosed.
Claims1
A cancer treatment combination for treating a susceptible tumor in a mammal, comprising:
- a therapeutically effective amount of (S)-2-(5(((1,2-dihydro-3-methyl-1-oxobenzo[f]quinazolin-9-yl)methyl)1-oxo-2-isoindolinyl)glutaric acid and folic acid in an amount effective to reduce said toxicity without blocking therapeutic effect of the [S]-2-(5-(((1,2-dihydro-3-methyl-1-oxobenzo[f]quinazolin-9-yl)methyl)amino)-1-oxo-2-isoindolinyl)glutaric acid.
Dependencies are inferred from the claim text.