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US 6,855,702 B2Granted
Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts, and mono-and di-amino acid ester salts
AssigneeBristol-Myers Squibb Company
InventorsJohn J. Venit, Mandar V. Dali, Manisha M. Dali, Yande Huang, Charles E. Dahlheim, Ravindra W. Tejwani
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Abstract
Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a result of the regeneration of combretastatin A-4.
Claims6
A compound having the structure of formula I:
- wherein:
- one of —OR1 or —OR2 is —O−QH+, and the other is hydroxyl or —O−QH+;
- and
- Q is
- an optionally substituted aliphatic organic amine containing at least one nitrogen atom which, together with a proton, forms a quaternary ammonium cation QH+.
2 more elements
A pharmaceutical composition comprising:
- (a) a compound having the structure of formula I:
- wherein:
- one of —OR1 or —OR2 is —O−QH+, and the other is hydroxyl or —O−QH+;
- and
- Q is
- an optionally substituted aliphatic organic amine containing at least one nitrogen atom which, together with a proton, forms a quaternary ammonium cation QH+;
- and
- (b) a pharmaceutically acceptable carrier thereof.
5 more elements
Dependencies are inferred from the claim text.