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US 6,855,696 B2Granted
Antitumor agents
AssigneeThe Regents of the University of California
InventorsTrevor C. McMorris, Michael J. Kelner
Life of this patent
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Abstract
The present invention provides illudin analogs of the general formula I: wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising compounds of formula I, intermediates and processes useful for preparing compounds of formula I, and methods comprising inhibiting tumor growth or treating cancer by administering one or more compounds of formula I.
Claims9
A compound of formula (I):
- wherein
- R1 is CH2-[sulfur-linked-cysteine]-Rx;
- R2 is methyl;
- R3 is hydrogen;
- R4 is methyl;
- R5 is hydroxy;
- and
- R6 is methyl;
- wherein Rx is a is -Leu-Leu-Leu, -Leu-Phe-Leu, -Leu-Gly-Leu, -Leu-Leu-Phe, -Leu-Phe-Phe, -Leu-Gly-Phe, -Leu-Leu-Gly, -Leu-Phe-Gly, -Leu-GIy-Gly, -Phe-Leu-Leu, -Phe-Phe-Leu, -Phe-Gly-Leu, -Gly-Leu-Leu, -Gly-Phe-Leu, -Gly-Gly-Leu, -Leu-Leu, -Phe-Leu, -Gly-Leu, -Lcu-Leu-Phe, -Phe-Phe-Phe, -Phe-Gly-Phe, -Gly-Leu-Phe, -Gly-Phe-Phe, -Gly-Gly-Phe, -Leu-Phe, -Phe-Phe, -Gly-Phe, -Phe-Leu-Gly, -Phe-Phe-Gly, -Phe-Gly-Gly, -Phe-Leu-Gly, -Gly-Phe-Gly, -Gly-Gly-Gly, -Leu-Gly, -Phe-Gly, or -Gly-Gly;
- or a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.