Stimulation of cartilage growth with agonists of the non-proteolytically activated thrombin receptor
AssigneeBoard of Regents, The University of Texas System
InventorsDarrell H. Carney, Roger S. Crowther, Janet Stiernberg, John Bergmann
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Abstract
Disclosed is a method of stimulating cartilage growth, repair or regeneration at a site in a subject in need of such growth, repair or regeneration. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site. Also disclosed is a method of stimulating the proliferation and expansion of chrondrocytes in vitro. The method comprises culturing chrondrocytes in the presence of a stimulating amount of an NPAR agonist.
Claims4
A method of stimulating cartilage growth at an arthritic joint in a subject, said method comprising the step of administering to the site a therapeutically effective amount of the peptide Ala-Gly-Try-Lys-Pro-Asp-Glu-Gly-Lys-Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val-NH2 (SEQ ID NO:
- 7).
A method of stimulating cartilage growth in a subject at a site being treated for cartilage loss, said method comprising the step of administering to the site a therapeutically effective amount of the peptide Ala-Gly-Try-Lys-Pro-Asp-Glu-Gly-Lys-Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val-NH2 (SEQ ID NO:
- 7).
A method of stimulating cartilage growth in a subject at a site being treated for cartilage loss due to traumatic injury, said method comprising the step of administering to the site a therapeutically effective amount of the peptide Ala-Gly-Try-Lys-Pro-Asp-Glu-Gly-Lys-Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val-NH2 (SEQ ID NO:
- 7).
A method of stimulating cartilage growth or repair at a site in a subject in need of such growth or repair, said method comprising the step of administering to the site a therapeutically effective amount of the peptide Ala-Gly-Try-Lys-Pro-Asp-Glu-Gly-Lys-Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val-NH2 (SEQ ID NO:
- 7).
Dependencies are inferred from the claim text.