Back to results
US 6,855,515 B1Granted
Autoantigenic fragments, methods and assays
AssigneesMerck & Co., Inc., The Johns Hopkins University
InventorsAnthony Rosen, Livia Casciola-Rosen, Donald W. Nicholson, Felipe A. Andrade, Sophie Roy, Nancy A. Thornberry
Life of this patent
Estimating the term…
Abstract
The present invention provides a method of producing autoantigens, compositions comprising autoantigenic fragments and methods of using autoantigenic fragments in the treatment of a condition associated with an autoimmune response. Also provided are assays for the detection or assessment of an autoimmune response.
Claims5
A method of making at least one human autoantigenic fragment from at least one human autoantigen selected from the group consisting of human DNA-PKCS and human NuMA, comprising the steps of
- (a) isolating cells containing at least one human autoantigen, and
- (b) contacting the cells with a lymphocyte granule enzyme to produce a mixture containing at least one human autoantigen fragment.
Dependencies are inferred from the claim text.