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US 6,855,340 B2Granted
Copper lowering treatment of inflammatory and fibrotic diseases
AssigneeThe Regents of the University of Michigan
InventorGeorge J. Brewer
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AssigneeThe Regents of the University of Michigan
InventorGeorge J. Brewer
Estimating the term…
The present invention relates generally to the field of prophylaxis and therapy for inflammatory and/or fibrotic diseases which include responses to injuries. In particular, the present invention is related to agents that can bind or complex copper such as thiomolybdate, and to the use of these agents in the prevention and treatment of inflammatory and/or fibrotic diseases. Exemplary thiomolybdates include mono-, di-, tri- and tetrathiomolybdate; these agents are administered to patients to prevent and/or treat inflammatory and/or fibrotic diseases, such as pulmonary disease including pulmonary fibrosis and acute respiratory distress syndrome, liver disease including liver cirrhosis and hepatitis C, kidney disease including renal interstitial fibrosis, scleroderma, cystic fibrosis, pancreatic fibrosis, keloid, secondary fibrosis in the gastrointestinal tract, hypertrophic burn scars, myocardial fibrosis, Alzheimer's disease, retinal detachment inflammation and/or fibrosis resulting after surgery, and graft versus host and host versus graft rejections.
A method of treating disease in a patient, wherein said disease is selected from the group consisting of pulmonary fibrosis, liver cirrhosis, and renal interstitial fibrosis, comprising administering to said patient having said disease a biologically effective amount of at least a first agent that binds or complexes copper wherein the first agent is a thiomolybdate.
A method of treating disease in a patient, wherein said disease is selected from the group consisting of pulmonary fibrosis, liver cirrhosis, and renal interstitial fibrosis, comprising administering to said patient having said disease a therapeutically effective amount of at least a first agent that binds or complexes copper wherein the first agent is a thiomolybdate.
Dependencies are inferred from the claim text.