Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol
AssigneeMemorial Sloan Kettering Cancer Center
InventorsRaymond P. Warrell, Jr., Pier Paolo Pandolfi, Janice L. Gabrilove
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Abstract
The invention relates to the use of arsenic compounds to treat a variety of leukemia, lymphoma and solid tumors. Further, the arsenic compounds may be used in combination with other therapeutic agents, such as a retinoid. The invention also provides a process for producing arsenic trioxide formulations.
Claims20
A method for treating acute promyelocytic leukemia, comprising determining a dosage amount of arsenic trioxide for the treatment of a patient diagnosed with acute promyelocytic leukemia, based on the weight of the patient and a dose of a therapeutically effective amount of about 0.15 mg/kg of patient body weight, and administering arsenic trioxide in said dosage amount to said patient for a maximum of 60 days or until bone marrow remission, wherein said administering constitutes a first administration.
A method for treating acute promyelocytic leukemia in a human, comprising administering a therapeutically effective amount of about 0.15 mg/kg arsenic trioxide once per day, for a maximum of 60 days or until bone marrow remission, wherein said administering constitutes a first administration.
Dependencies are inferred from the claim text.