Surface coating spatially controlled patterns
AssigneesMassachusetts Institute of Technology, The University of Nottingham
InventorsKevin Shakesheff, Nikin Patel, Scott M. Cannizzaro, Robert S. Langer
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Abstract
The invention provides a biodegradable and biocompatible polymer article having a surface wherein a biologically active ligand is provided on said surface in a spatially controlled pattern. The pattern may be formed using a poly(dimethyl siloxane) mold. The biologically active ligand may be attached to the polymer article by a biotin-avidin-biotin linkage.
Claims47
A biodegradable and biocompatible article comprising a biologically active ligand bound to the surface of said biodegradable and biocompatible article in a spatially controlled pattern,
- wherein the biologically active ligand is attached to the surface via a specific molecular interacton with an adapter compound, the adapter compound being attached to the surface by means of aspecific molecular interaction with an anchor molecule provided on the surface of the article, and
- wherein the specific molecular interaction has a Kd between 10−10 and 10−17 M.
A process of forming a biodegradable and biocompatible article comprising,
- providing on a surface of an article a biologically active ligand in a spatially controlled pattern,
- wherein the biologically active ligand is attached to the surface via a specific molecular interaction with an adapter compound, the adapter compound being attached to the surface by means of a specific molecular interaction with an anchor molecule provided on the surface of the article, and
- wherein the specific molecular interaction has a Kd between 10−10 and 10−17 M.
A biodegradable and biocompatible article having a surface wherein an adapter compound, which is attached to the s&surface by binding by means of a specific molecular interaction to an anchor molecule provided on the surface, is provided on the surface in a spatially controlled pattern,
- wherein the adapter molecule is suitable for attaching a biologically active ligand to the surface via the adapter molecule by means of a specific molecular interaction between the adapter molecule and the biologically active ligand, and
- wherein the specific molecular interaction has a Kd between 10−10 and 10−17M.
Dependencies are inferred from the claim text.