Skin protection composition
AssigneeThe Procter & Gamble Company
InventorsGianfranco Palumbo, Mario Guarracino
Life of this patent
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Abstract
The invention relates to cationic compounds and triester compounds to be used for preparation of compositions, which preferably can be in the form of lotions, creams, powders, oils, foams and the like, and be applied to the skin to prevent or reduce or treat skin rash or diaper rash resulting from lypolytic dermatitis. The compositions of the invention can also be applied to diapers, incontinent-pads, wipes and the like. The invention also relates to the use of such a composition to prevent or reduce such a skin rash and a process for reducing the enzyme activity enzymes which are deactivated when the pH is reduced, such as lipase enzymes present on external skin.
Claims18
A composition for the reduction of lipase enzyme activity on skin, said composition comprising:
- (a) a compound of the formulation:
- wherein R1, R2 and R3 are independently an alkyl or alkenyl or hydroxyalkyl group with from 1 to 22 carbon atoms, and R4, R5, R6, R7 and R8 are independently selected from the group consisting of C1-C10 linear or branched alkyl, alkenyl or hydroxyalkyl groups, hydroxy, chloride, bromide, amine or hydrogen;
- and
- (b) a compound of the formulation:
- an amphoteric compound, said amphoteric compound having at its iso-electric point the formula:
- wherein R1, R2, R3 and R4 are independently selected from the group consisting of C1-C22 linear or branched alkyl, alkenyl, aryl, arylalkyl, amidoalkyl, (poly) alkoxy, hydroxyalkyl, or acyl groups, or two or more groups of R1, R2, R3 and R4 form together one or more ring structures;
- R5, R6 and A are independently selected from the group consisting of C1-C22 linear or branched alkylene, alkenylene, (poly) alkoxylene, hydroxyalkylene, arylalkylene or amido alkylene groups;
- R7 and R8 are independently an C1-C4 alkyl, alkenyl, alkoxy group or a hydroxy group or hydrogen;
- R9 and R10 are independently selected from the group consisting of C1-C22 linear or branched alkyl, alkenyl, aryl, arylalkyl, amidoalkyl, (poly) alkoxy, hydroxyalkyl, or acyl groups, or two or more of the groups R1, R9 and R10 form together one or more ring structures;
- BH is a proton donating group;
- x is from 2 to 4;
- and M− is a counter ion;
- and
- wherein said composition within the first 15 minutes of application of said composition to an affected area, reduces the lipase enzyme activity to 35% of initial lipase activity in said affected area.
A method for reducing the lipase enzyme activity in an affected area comprising the steps of administering to said affected area of a subject a composition comprising:
- (a) a compound of the formulation:
- wherein R1, R2 and R3 are independently an alkyl or alkenyl or hydroxyalkyl group with from 1 to 22 carbon atoms, and R4, R5, R6, R7 and R8 are independently selected from the group consisting of C1-C10 linear or branched alkyl, alkenyl or hydroxyalkyl groups, hydroxy, chloride, bromide, amine or hydrogen;
- and
- (b) a compound of the formulation:
- an amphoteric compound, said amphoteric compound having at its iso-electric point the formula:
- wherein R1, R2, R3 and R4 are independently selected from the group consisting of C1-C22 linear or branched alkyl, alkenyl, aryl, arylalkyl, amidoalkyl, (poly) alkoxy, hydroxyalkyl, or acyl groups, or two or more groups of R1, R2, R3 and R4 form together one or more ring structures:
- R5, R6 and A are independently selected from the group consisting of C1-C22 linear or branched alkylene, alkenylene, (poly) alkoxylene, hydroxyalkylene, arylalkylene or amido alkylene groups;
- R7 and R8 are independently and C1-C4 alkyl, alkenyl, alkoxy group or a hydroxy group or hydrogen;
- R9 and R10 are independently selected from the group consisting of C1-C22 linear or branched alkyl, alkenyl, aryl, arylalkyl, amidoalkyl, (poly) alkoxy, hydroxyalkyl, or acyl groups, or two or more of the groups R1, R9 and R10 form together one or more ring structures;
- BH is a proton donating group:
- x is from 2 to 4;
- and M− is a counter ion;
- and
- wherein said method within the first 15 minutes of application of said composition to said affected area, reduces said lipase enzyme activity to 35% of initial lipase activity in said affected area.
Dependencies are inferred from the claim text.