Identification of the domain of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) that mediates adhesion to chondroitin sulfate A
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsArtur Scherf, Louis H. Miller, Benoit Gamain, Dror I. Baruch, Pierre Buffet, Christine Scheidig, Jurg Gysin, Bruno Pouvelle, Nobutaka Fujii, Joseph Smith
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Abstract
The present invention relates to the discovery of a var gene and corresponding protein that modulates adhesion of parasitized red blood cells to chondroitin sulfate A. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.
Claims8
A purified or isolated protein comprising the sequence of SEQ ID NO:2.
A purified or isolated polypeptide comprising a DBL3 domain of residues 1279-1554 of SEQ ID NO:2 or an immunogenic fragment thereof consisting of at least 15 or 30 amino acids of residues 1279-1554 of SEQ ID NO:2.
Dependencies are inferred from the claim text.